Silver nanoparticles (Ag Nps), are among the most attractive nanomaterials have been widely used in a range of biomedical applications, including diagnosis treatment, drug delivery, medical device coating, and for personal health care 3. The metal and metal oxide nanoparticles either sole or in nanocomposite structures increased the antimicrobial activity by the virtue of expanding spectrum of enhanced features 2. Recently, nanotechnology with its related products opens different avenues to face and solve the MDR threat. However, the intense and widespread abuse of such biocides led to emergence of multi-drug resistant microbes (MDR). As a result, various antimicrobial agents, particularly antibiotics, were developed to combat the spread of pathogen-causing infections. The microbes causing infectious diseases are ubiquitous through several routes such as food manufacturing machines, water purification systems and polluted medical devices 1. Nonetheless, their pathogenicity represents a serious problem for public health and the entire ecosystem. Several benefits are provided by them in maintaining a balanced ecosystem, such as oxygen generation, nutrient supplementation, organic material decomposing and bioactive compounds production. Through assessing cytotoxicity, 2O NCs exhibited higher safety against Vero cells than bulk silver nitrate by more than 100-fold.Įarth’s biosphere is occupied by a plethora of microorganisms which encompass several categories, including bacteria, archaea, yeast, molds, algae, viruses and protozoa. Interestingly, a remarkable mycocidal potency by 50 μg of 2O NCs against Candida albican implying promising activity against COVID-19 white fungal post-infections. 2O NCs exhibited higher antimicrobial, antibiofilm, and algicidal activity in dose-dependent behavior. Additionally, zeta potential and fluorescence spectra illustrated aggregated nature of 2O NCs by − 5.34 mV with fluorescence emission peak at 498 nm. Besides, SEM and HRTEM micrographs depicted spherical nanoparticles with size range of 19–60 nm. XRD, Raman, FTIR, XPS and SAED analysis revealed a crystalline hybrid structure of Ag core and Ag 2O shell. Several techniques were used to determine the structural, morphological, and optical characteristics of the as-prepared NCs. In the current study, a facile, novel and cost-effective approach was applied to synthesize 2O core–shell nanocomposites (NCs) via chemical method.
To circumvent such a multidrug-resistance phenomenon, well-defined nanocomposite structures have recently been employed. The continuous misuse and overutilization of antibiotics participate mainly in the emergence of microbial resistance. Microbial contamination is one of the major dreadful problems that raises hospitalization, morbidity and mortality rates globally, which subsequently obstructs socio-economic progress.
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